Pleural mesothelioma
Ajouté le 26/6/2011
Mesothelioma is a malignant tumor of the mesothelium, envelope consists of two layers between which is a liquid lubricant. The mesothelium surrounds many organs: it called for the lung pleura, peritoneum for the digestive organs, pericardium to the heart.
The most common is that of the pleura: pleural mesothelioma is
It is almost always secondary to the inhalation of asbestos dust (this is known since the 60s) and possibly some refractory ceramic fibers. Microfibers inhaled asbestos will stay deep in the respiratory tree in the cells, these high strength fibers migrate to the pleura where mechanical irritation of the pleura, the lesion base is primarily physical, not chemical. The period between exposure and disease, often by several decades but can be shorter in some cases. This exposure may be short (one or two years) and therefore difficult to find and prove 40 or 50 years later.
Mesothelioma is one of the pathologies induced by asbestos (see our article on the subject)
Smoking increases the risk of lung injury but does not affect the risk of developing mesothelioma.
The signs of the disease are not very evocative and often late: Chest pain, neuralgia in the arm, back pain in the shoulder blade. Therefore considered rather banal
More evocative: pleural effusion (fluid between the often bloody layers of the pleura) with dyspnea (breathlessness),
The chest X-ray is rarely useful except in advanced stages.
Microscopic examination of the aspirate in an effusion of malignant cells can be found
CT and MRI examinations are the most useful and diagnosis will be confirmed by a biopsy of the pleura or by thoracoscopy
Treatment: early surgery can produce results, then radiation therapy can slow the progression, and finally chemotherapy will be only palliative. The prognosis is generally awful (one year survival in many cases only).
Prevention is essential: removal of sprayed asbestos, protection of workers and their families (wife cleans clothes for example)
Asbestos is banned in France since 1997, and in many western countries (but there are other countries where everything needs to be done ...)
Occupations at risk are numerous.
Those who pay the highest price has been, is and will be (the maximum number of cases is expected between 2010 and 2020):
Plumbers, welders, pipefitters
Workers in the construction of iron or steel (carpenters, shipbuilding and rail car)
Sheet metal workers, boilermakers, auto mechanics and truck
Electricians
Construction workers in general
DIYers "madmen"
Employment in the manufacture of asbestos (asbestos cement, asbestos textile industry until 1996 with activity of carding, spinning or weaving)
Employment in the insulation (thermal or sound) in the manufacture of electrical insulators in power stations, refineries
Auto repair and other vehicles (brakes and clutch)
Assemblers in ventilation / heating / cooling, boiler installer
Steel industry (blast furnaces, coke ovens, steel mills)
Glass Industry
Tags : Pleural mesothelioma
Catégorie : Mesothelioma cancer
| Commentaires (0) |
Ecrire un commentaire |
Mesothelium
Ajouté le 25/6/2011
The mesothelium has two layers, one surrounding the body itself, and the other forms a sac around it completely. A small amount of fluid is normally produced between these two layers, lubricating the movement of organs protected.
When normal cells of the mesothelium lose control and spread rapidly, they produce mesothelioma.
The form of mesothelioma is the most common pleural mesothelioma.
It occurs in the pleura, the lining of the lungs. Other forms are peritoneal mesothelioma, reaching the peritoneum lining the abdominal cavity and pericardial mesothelioma, the pericardium.
The occurrence of this disease, sometimes referred to asbestos cancer, this fiber is the main risk factor known for this type of cancer is not indicative of a minimum of exposure and medical treatment has an impact limited life expectancy of patients, usually 12 to 18 months.
A real market for lawyers mesothelioma cancer exists in the United States, some keywords are present, for example: mesothelioma lawyers, mesothelioma attorneys, mesothelioma also Treatments or mesothelioma.
The first signs found on clinical examination are chest pain, often associated with shortness of breath and recurrent pleural effusion, usually bleeding. The latency between first exposure and the development of mesothelioma is seldom less than 20 years, often in the range of 30 to 40 years or more. It does not seem to value threshold of exposure related to a risk of occurrence.
It has been described in cases of pleural mesothelioma occurring in the family environment close to the workers exposed to asbestos, the subjects being exposed due to the contamination of residential premises or in the maintenance of dusty clothes.
Tobacco plays a synergistic cofactor in the risk of developing mesothelioma.
Tags : mesothelium cancer
Catégorie : Mesothelioma cancer
| Commentaires (0) |
Ecrire un commentaire |
Pathology
Ajouté le 25/6/2011
Development first on the parietal pleura of
No demonstration that the pleural plaques are associated with an increased risk of mesothelioma.
Predominant form epithelioid; mixed forms and sarcomatoid rare.
Immunohistochemical staining to distinguish: epithelioid mesothelioma and adenocarcinoma: marker associated with mesothelioma: calretinin, podoplanine, WT1, cytokeratin 5 / 6.
Distinction sarcomatoid mesothelioma and sarcomatoid carcinoma or sarcoma, very difficult.
Attempts screening assay circulating mesothelin: inconclusive. Tags : Pathology anatomy
Catégorie : Mesothelioma symptoms
| Commentaires (0) |
Ecrire un commentaire |
Historical of cancer
Ajouté le 21/6/2011
An article published by Wagner et al in 1960 established for the first time that mesothelioma is a disease resulting from exposure to asbestos in the form of crocidolite12. The article lists more than 30 cases of patients who had mesothelioma in South Africa including temporary exhibitions and cases involving minors.
In 1962 Dr McNulty reported the first case of malignant mesothelioma diagnosed in Australia in a worker exposed to amiante13. The worker had worked in the mill at the asbestos mine in Wittenoom from 1948 to 1950.
In the town of Wittenoom, packaging waste of asbestos from the mine were recycled in the coating of playgrounds and playground
In 1965 it was established in an article in the British Journal of Occupational Medicine that people who had lived in the neighborhood of factories and asbestos mines, but without work, had contracted mesothelioma.
Despite evidence that the dust associated with the operation of the mine and milling of asbestos fibers was indeed the cause of diseases related to asbestos mining began at Wittenoom in 1943 continued until 1966.
It is difficult to understand why they allowed the mine and the mill first opened and continue to operate without appropriate measures to control risk, and why nothing was done to force the owner (CSR) get the standards, adopt safer work practices or to cease operations.
In 1974 the first public warnings about the dangers of blue asbestos were published in the newsletter of the Australian magazine as a bound book whose cover was titled: "Is this Killer in Your Home? "
In 1978 the Government of Western Australia has decided to raze the town of Wittenoom, following the publication of a booklet of the health service, "the health risk to Wittenoom", containing the results of air samples and an evaluation of medical data available worldwide.
In 1979 the first complaints of neglect Wittenoom were launched against CSR and its subsidiary ABA, and asbestos disease society was formed to represent the Wittenoom victims. Tags : hostorical mesothelioma
Catégorie : Mesothelioma cancer
Treatment of cancer
Ajouté le 20/6/2011
The mesothelioma treatment by conventional therapies has not proved effective and patients have a median survival of 6 to 12 months after diagnosis. The degree of malignancy of the tumor depends on several factors including the total mesothelial surfaces of the pleural cavity which promotes the importance of local metastasis via exfoliated cells and the invasion of underlying tissue and other organs in the pleural cavity. Another factor involved is the extremely long latency period between exposure to asbestos and the development of the disease. Surgery There are two types of surgery. The partial pleurectomy lightest and extended pleurotectomie that involves removing the pleura and lung block. In some cases, surgery may significantly increase the survival expectancy. Radiotherapy Chemotherapy In February 2004, the Food and Drug Administration approved the use of pemetrexed for the treatment of malignant pleural mesothelioma. The use of this drug is legal in France since 2005. Raltitrexed in turn is being recorded in France and should get his MA in early 2011. The addition of bevacizumab to chemotherapy (gemcitabine + cisplatin) appears to be décevant10. A European trial (IFCT-0701 MAPS) is ongoing to assess the value of bevacizumb in combination with standard chemotherapy (pemetrexed + cisplatin). Other protocols have been tried with moderate efficacy, survival compared to more conventional treatment not exceeding a few months11. Immunotherapy Treatment protocols involving treatment with immunotherapy have yielded variable results. For example, intrapleural inoculation of Bacillus Calmette-Guerin (BCG) in an attempt to boost the immune response, proved of no benefit to the patient (while it can improve the patients of bladder cancer). It has been shown in vitro that mesothelioma cells were destroyed by lymphocytes following activation by interleukin-2 (IL-2), but patients undergoing this particular therapy have experienced major side effects. Indeed, this clinical trial was halted because of unacceptably high levels of toxicity of IL-2 and severity of side effects such as fever and cachexia. However, other trials using interferon alpha have been encouraging with 20% of patients with greater than 50% reduction in tumor mass combined with minimal side effects. Tags : mesothelioma treatment
Catégorie : Mesothelioma cancer
| Commentaires (0) |
Ecrire un commentaire |
|
